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Flucloxacillin is an antibiotic that belongs to a group of medicines called penicillins. These medications work by killing the bacteria that cause an infection. It is used to treat infections caused by bacteria. Examples of infections that can be caused by bacteria include respiratory tract infections and skin infections or skin infections of meat tissue. Flucloxacillin is not effective against infections caused by viruses, such as colds or flu.

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Flucloxacillin 500 mg | Before taking flucloxacillin

Warning: Flucloxacillin can cause serious liver damage, especially in elderly
patients and those who use it for more than 14 days .

When you shouldn’t take it

Do not take flucloxacillin if you are allergic to:
• Medicines containing flucloxacillin or other penicillins;
• Cephalosporin antibiotics;
• Beta-lactam antibiotics;
• Any of the ingredients listed at the end of this leaflet.
Some symptoms of an allergic reaction may include a rash, itching or hives, swelling of the face, lips, tongue or other parts of the body, shortness of breath, wheezing or difficulty breathing.

Do not use flucloxacillin if you have had a reaction affecting your liver while taking a medicine containing flucloxacillin. Examples of liver reactions include hepatitis and jaundice (yellowing of the eyes or skin).

Do not use flucloxacillin if the expiration date has passed. If you are unsure about whether to start taking Flucloxacillin, contact your doctor.

Flucloxacillin | Before you use it

Talk to your doctor or pharmacist before taking this medicine:

If you are using or are going to use paracetamol

There is a risk of blood and fluid abnormalities (high anion metabolic acidosis) if plasma acidity increases when flucloxacillin is used concomitantly with paracetamol, particularly in certain risk groups, such as patients with severe renal impairment, sepsis, or malnutrition, especially when the maximum daily dose of paracetamol is used. High anion metabolic acidosis is a serious condition requiring urgent treatment.

Tell your doctor if you are allergic to any other medicines, foods, dyes, or preservatives.

Tell your doctor if you have any medical conditions, especially the following:
• liver problems;
• kidney problems;
• asthma, hay fever, eczema or other allergic conditions.

Tell your doctor if you are pregnant or planning to become pregnant. Your doctor will discuss the risks and benefits of taking flucloxacillin during pregnancy.

Tell your doctor if you are breastfeeding or plan to breastfeed. A very small amount of flucloxacillin passes into breast milk. Your doctor will discuss the risks and benefits of taking flucloxacillin while breastfeeding.

If you have not told your doctor about any of the above, tell your doctor before you start taking flucloxacillin.

This medicine may cause adverse effects (e.g., allergic reactions, dizziness) that could affect your ability to drive or operate machinery. You should exercise caution when driving or operating machinery.

Flucloxacillin fk | Using other medications

Tell your doctor if you’re taking any other medications, including those you buy without a prescription at your pharmacy, supermarket, or health food store. Also tell any healthcare provider who prescribes a new medication that you’re taking flucloxacillin.

Some medicines can interfere with the way flucloxacillin works. These include:
• Probenecid, a medicine used to treat gout;
• Some antibiotics, such as tetracycline and macrolide antibiotics.

These medicines may be affected by flucloxacillin or affect its effectiveness. You may need different doses of your medicine, or you may need to take different medications.

Some antibiotics can reduce the effectiveness of some birth control pills, although this has not been shown with flucloxacillin. Talk to your doctor about the need for additional contraception while taking flucloxacillin.

Your doctor or pharmacist has more information on medicines to be careful with or avoid while taking flucloxacillin.

How is flucloxacillin taken?

How much to take

Your doctor will tell you how much to take each day and when to take it. This will depend on your condition and whether you are taking other medications.

For most infections, the usual dose for adults is 250 mg every six hours, but this depends on the severity of the infection.

If you have kidney problems, your doctor may tell you to take a lower dose. Follow all your doctor’s instructions carefully.

Swallow the capsules whole with a glass of water. Take flucloxacillin on an empty stomach, for example, half an hour before a meal or just before going to bed. Food can interfere with the absorption of flucloxacillin.

How long should you take it?

Continue taking flucloxacillin until you finish the pack, or for as long as your doctor recommends. Don’t stop taking flucloxacillin, even if you feel better after a few days, unless your doctor tells you to. Your infection may not clear up completely if you stop taking your medication too soon.

Did you forget to take flucloxacillin?

If it’s almost time for your next dose, skip the missed dose and take your next dose at the correct time. Otherwise, take the missed dose as soon as you remember, and then continue taking your capsules as usual.

Do not take a double dose to make up for a missed dose.

If you are not sure what to do, ask your doctor or pharmacist for advice.

Flucloxacillin side effects

Like all medicines, flucloxacillin can cause side effects in some people, although not everyone gets them.

Common side effects

Common side effects of flucloxacillin affect more than 1 in 100 people. Keep taking the medicine, but tell your doctor or pharmacist if these side effects bother you or don’t go away:

to be sick (nausea) or to be sick (vomiting);
diarrhea;
bloating and indigestion;

Serious side effects

Serious side effects are rare and affect less than 1 in 1,000 people.

Call a doctor if:

you get diarrhea (possibly with muscle cramps) containing blood or mucus, or severe diarrhea that lasts more than 4 days;
You have pale stools with dark urine and the whites of your eyes or skin turn yellow (this may be less noticeable with black or light brown skin) – this could be a sign
if you have liver problems;
You get bruises or discolored skin;
You have joint or muscle pain that starts after 2 days of taking the medicine;

Some of these serious side effects may not occur until up to two months after stopping treatment with flucloxacillin.